A trio of angels - Monica (Roma Downey), Tess (Della Reese), and Andrew (John Dye) - are dispatched from heaven with a special mission: to inspire people facing sometimes unseen crossroads in their lives. Monica, an angel who at times still needs some guidance with her earthly assignments, reports to Tess, her tough, wise and always loving supervisor.

Also on hand is Andrew, who, in addition to his duties as the Angel of Death, now helps out as a caseworker on various assignments. Gloria (Valerie Bertinelli), an angel for the 21st century, continues to seek guidance from Monica performing her angelic duties.

The angels commitment to the quest and their eternal love for mankind is unquestioned. Often it is the journey, not the destination, that reveals the true miracles of life.